Ammonia → HCID 136343466, compound

HRID 1594068Notes

Reaction equation

HRID 1594068 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:11]2[NH:12][CH:13]=[CH:14][N:15]=2)[S:9][CH:10]=1)=O)C.[NH3:16]>CO>[NH:15]1[CH:14]=[CH:13][N:12]=[C:11]1[C:8]1[S:9][CH:10]=[C:6]([C:4]([NH2:16])=[O:3])[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 136343490HCID 136343490, compound

Product 1

HCID 136343466HCID 136343466, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 2-(1H-Imidazole-2-yl)-thiazole-4-carboxylic acid ethyl ester (190 mg) in 5 mL of MeOH is saturated with NH3 gas, and heated at 60° C. in a sealed tube overnight. After cooled, the reaction mixture is transferred to a round bottle flask and evaporated in vacuo to a solid. LRMS calcd 194, found 195 (MH+).

Workup

  1. temperatureAfter cooled
  2. customthe reaction mixture is transferred to a round bottle flask
  3. customevaporated in vacuo to a solid

Sources & evidence

ORD record
ord-a8697457e2ca475a9be6a38e48f61c92
Source dataset
uspto-grants-2007_11
Patent number
US07300945B2

Reaction notes

Loading…