Lithium diisopropylamide → HCID 66774536, compound

HRID 1594190Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][N:9]2[C:13]3[CH:14]=[C:15]([C:18]4[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=4[C:20]([OH:22])=[O:21])[CH:16]=[CH:17][C:12]=3[N:11]=[CH:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CON(C)[C:30](=[O:41])[C:31]1[CH:36]=[C:35]([O:37][CH3:38])[CH:34]=[C:33]([O:39][CH3:40])[CH:32]=1.C([N-]C(C)C)(C)C.[Li+]>>[CH3:40][O:39][C:33]1[CH:32]=[C:31]([CH:36]=[C:35]([O:37][CH3:38])[CH:34]=1)[C:30]([C:10]1[N:9]([CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:13]2[CH:14]=[C:15]([C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[C:20]([OH:22])=[O:21])[CH:16]=[CH:17][C:12]=2[N:11]=1)=[O:41]

Participants

Reactant 3

HCID 2724682Lithium diisopropylamide

HCID 11117713N,3,5-Trimethoxy-N-methylbenzamide

HCID 69245142HCID 69245142, compound

Product 1

HCID 66774536HCID 66774536, compound

Procedure

2-[1-(2-phenylethyl)-1H-benzimidazole-6-yl]benzoic acid and N,3,5-trimethoxy-N-methylbenzamide were subjected to a reaction in the presence of lithium diisopropylamide to give the compound having the following physical data.

Workup

customto give the compound

Sources & evidence

ORD record: ord-1907e5008cdd47179a694f673c9ccb2e
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07300917B2

Reaction notes

Loading…