Dimethylamine → HCID 59432814, compound

HRID 1594211Notes

Reaction equation

HRID 1594211 reaction equation
[C:1]([C@H:4]([N:9]([CH2:20][C:21]1[CH:32]=[CH:31][C:24]([CH2:25]OS(C)(=O)=O)=[CH:23][CH:22]=1)[S:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH2:5][CH:6]([CH3:8])[CH3:7])(=[O:3])[NH2:2].C[CH2:34][N:35](CC)[CH2:36]C.CNC>C(Cl)Cl>[Cl:19][C:16]1[CH:15]=[CH:14][C:13]([S:10]([N:9]([C@H:4]([CH2:5][CH:6]([CH3:7])[CH3:8])[C:1]([NH2:2])=[O:3])[CH2:20][C:21]2[CH:22]=[CH:23][C:24]([CH2:25][N:35]([CH3:36])[CH3:34])=[CH:31][CH:32]=2)(=[O:12])=[O:11])=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 8471TriethylamineHCID 59001047HCID 59001047, compound

Product 1

HCID 59432814HCID 59432814, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred solution of methanesulfonic acid 4-{[N-((1R)-1-carbamoyl-3-methyl-butyl)-N-(4-chlorobenzenesulfonyl)amino]-methyl }-benzyl ester (150 mg, 0.298 mmol) in (3 mL) CH2Cl2 at 0° C. was added 1 equivalent of Et3N, followed by dimethylamine (0.3 mL, 2 M in THF). The reaction was stirred overnight at rt. The mixture was diluted with CH2Cl2, washed with H2O, brine, dried over MgSO4, and concentrated to give an amber glass. Purification by flash chromatography (SiO2, 10% MeOH/CH2Cl2) afforded the title compound (95 mg) in 71% yield. MS (ESI), (M+H)+452.23, 1H NMR (CDCl3) δ7.94 (d, 2H, J=8.0), 7.74 (d, 2H, J=8.0), 7.63 (d, 2H, J=8.0) 7.38 (d, 2H, J=8.0), 6.23 (br s, 1H), 5.35 (br s, 1H), 4.22 (d, 1H, Jab=16), 4.14 (d, 1H, Jab=16), 3.28-3.23 (m, 3H), 2.17 (br s, 6H), 1.95 (m, 1H), 1.55 (m, 2H), 0.96 (d, 3H, J=7.0), 0.93 (d, 3H, J=7.0).

Workup

  1. washwashed with H2O, brine
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated
  4. customto give an amber glass
  5. customPurification by flash chromatography (SiO2, 10% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-b1be563dd7ca45ada43cc88871d27068
Source dataset
uspto-grants-2007_11
Patent number
US07300936B2

Reaction notes

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