反应详情

To the mixture of 2a (20 mg, 0.104 mmol) in CH2Cl2 (10 mL) was added chlorosulfonyl isocyanate (15 μL, 0.15 mmol). The resultant mixture was stirred at room temperature for 1 h and mixed with water (0.5 mL). Separation via a reverse phase HPLC provided the title compound (10 mg, 40%) as a white solid: MS (ES) m/z 236 (M+H)+; 1H NMR (400 MHz, DMSO-d6) δ10.77 (s, 1H), 7.84 (m, 2H), 7.56 (brs, 3H), 7.20 (m, 1H), 7.08 (m, 1H), 6.98 (brs, 1H).

1. customSeparation via a reverse phase HPLC