Ethanolamine → HCID 22480351, compound

HRID 1594262Notes

Reaction equation

HRID 1594262 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH2:5]([N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([C:21]2[O:22][C:23]([C:26](Cl)=[O:27])=[CH:24][CH:25]=2)=[N:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1COCC1>[CH2:5]([N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([C:21]2[O:22][C:23]([C:26](=[O:27])[NH:4][CH2:3][CH2:1][OH:2])=[CH:24][CH:25]=2)=[N:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 22480358HCID 22480358, compound

Product 1

HCID 22480351HCID 22480351, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

0.23 g (3.7 mmol) of ethanolamine were initially charged in 20 ml of THF and a solution of 0.5 g (1.5 mmol) of 1-benzyl-3-(5-chlorocarbonyl-2-furyl)indazole in 10 ml of THF was added dropwise. After 0.75 h, the mixture was poured into ice-water and the precipitate was filtered off with suction and recrystallized from ethyl acetate. This gave 0.33 g (62%) of the title compound. m.p.: 119-127° C.

Workup

  1. filtrationthe precipitate was filtered off with suction
  2. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-b47d66d27ee249349292f4df22752777
Source dataset
uspto-grants-2007_11
Patent number
US07300950B2

Reaction notes

Loading…