反应详情

温度

0 °C

To a solution of 1-iodo-3,3,3-trifluoropropane (19.3 g, 86.1 mmol) in toluene (50 mL) at 23° C. was added triphenylphosphine (25.8 g, 98.5 mmol). The reaction mixture was warmed to reflux and stirred for 28 h. The resulting mixture was cooled to 0° C. in an ice bath and filtered to collect the white solid product. The product was washed with toluene (3×) and air-dried to afford the pure product as white solid (33.4 g, 80%).

1. temperatureThe reaction mixture was warmed
2. temperatureto reflux
3. filtrationfiltered
4. customto collect the white solid product
5. washThe product was washed with toluene (3×)
6. customair-dried