Trifluoroacetic acid → 4-(Morpholin-4-yl)butan-2-amine

HRID 1594368Notes

Reaction equation

HRID 1594368 reaction equation
C(OC([NH:8][C@@H:9]([CH3:18])[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:8][CH:9]([CH3:18])[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69267290HCID 69267290, compound

Product 1

HCID 167672994-(Morpholin-4-yl)butan-2-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

The product of example 22 (c) (0.41 g, 1.59 mmol) was dissolved in CH2Cl2 (10 mL) and cooled in an ice bath while stirring under argon. A solution of trifluoroacetic acid (5 mL) in CH2Cl2 (5 mL) was added and the mixture allowed to warm to room temperature for 1 h. The solvents were evaporated to give the title compound as an oil. ES (+) MS m/e=159 (MH+)

Workup

  1. temperaturecooled in an ice bath
  2. customThe solvents were evaporated

Sources & evidence

ORD record
ord-5ffa9c308d6645e98bdf5a8b0ee6a884
Source dataset
uspto-grants-2007_11
Patent number
US07301021B2

Reaction notes

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