反应详情

温度

70 °C

Methyl 3-hydroxybenzoate (3.0 g, 19.7 mmol) was dissolved in 50 mL of acetonitrile and K2CO3 (3.27 g, 23.7 mmol) was added. The resulting mixture was reacted with N-(4-bromobutyl)phthalimide (6.68 g, 23.7 mmol) and KI (3.93 g, 23.7 mmol) and stirred overnight at 70° C. Following the addition of water, the resulting mixture was extracted with chloroform. The organic layer was washed with brine. The organic layer was dried with sodium sulfate and then concentrated under reduced pressure, followed by recrystallization with n-hexane/ethyl acetate to give a white crystal (6.60 g, 94.8%).

1. extractionthe resulting mixture was extracted with chloroform
2. washThe organic layer was washed with brine
3. dry with materialThe organic layer was dried with sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customfollowed by recrystallization with n-hexane/ethyl acetate