Hydrochloric Acid → 2-(3-Hydroxypropoxy)propan-1-ol

HRID 1594455노트

반응식

HRID 1594455 반응식
[OH:1][CH2:2][CH2:3][CH2:4][O:5][CH:6]([CH2:8][O:9]C(C)(C)C)[CH3:7].Cl>>[OH:1][CH2:2][CH2:3][CH2:4][O:5][CH:6]([CH2:8][OH:9])[CH3:7]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 1643333-[(1-Tert-butoxypropan-2-yl)oxy]propan-1-ol

생성물 1

HCID 217585032-(3-Hydroxypropoxy)propan-1-ol수율 91.3%

실험 절차

HO(CH2)3OCH(CH3)CH2OC(CH3)3 (203.39 g) prepared in Example 2-2 was loaded into a round-bottomed flask and stirred with 5 N hydrochloric acid (1 L) at room temperature for 43 hours. The reaction solution was concentrated with an evaporator, and then, after addition of toluene, concentrated again with an evaporator to give the title compound (131 g). The NMR spectrum data of the product were as follows.

후처리

  1. concentrationThe reaction solution was concentrated with an evaporator
  2. additionafter addition of toluene
  3. concentrationconcentrated again with an evaporator

출처 및 근거

ORD 기록
ord-0fc9a29fe2784e7a8d45b7afe5142329
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07301052B2

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