Acetone → HCID 58691386, compound

HRID 1594469Notes

Reaction equation

HRID 1594469 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C@H:6]([NH:8][C:9]1[C:14]([C:15]2[N:20]=[CH:19][N:18]=[C:17]([O:21][C:22]3[C:27]4[N:28]=[C:29]([NH:31][C:32](=[O:34])[CH3:33])[S:30][C:26]=4[CH:25]=[CH:24][CH:23]=3)[CH:16]=2)=[CH:13][CH:12]=[C:11]([C:35]([F:38])([F:37])[F:36])[N:10]=1)[CH3:7].[CH3:39][C:40]([CH3:42])=O>>[CH:40]([N:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C@H:6]([NH:8][C:9]1[C:14]([C:15]2[N:20]=[CH:19][N:18]=[C:17]([O:21][C:22]3[C:27]4[N:28]=[C:29]([NH:31][C:32](=[O:34])[CH3:33])[S:30][C:26]=4[CH:25]=[CH:24][CH:23]=3)[CH:16]=2)=[CH:13][CH:12]=[C:11]([C:35]([F:38])([F:36])[F:37])[N:10]=1)[CH3:7])([CH3:42])[CH3:39]

Participants

3

Reactant 2

HCID 180AcetoneHCID 58691363HCID 58691363, compound

Product 1

HCID 58691386HCID 58691386, compound

Procedure

N-(4-(6-(2-((R)-1-((R)-Pyrrolidin-2-yl)ethylamino)-6-(trifluoromethyl)pyridin-3-yl)-pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide, Example 12(d), (135 mg, 0.25 mmol) was reacted with acetone (56 μL, 0.75 mmol, Aldrich) under the conditions of Example 3(d) to give the title compound as a yellow solid. MS (ESI, pos. ion.) m/z: 586 (M+1).

Sources & evidence

ORD record
ord-c32099d3c0d7438d9fad3e15ad0ec961
Source dataset
uspto-grants-2007_11
Patent number
US07301022B2

Reaction notes

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