Isobutyraldehyde → HCID 58691420, compound

HRID 1594475Notes

Reaction equation

FC(F)(F)C(O)=O.[C:8]([NH:11][C:12]1[S:13][C:14]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[N:27]=[CH:26][N:25]=[C:24]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:29]=4[NH:38][C:39]([C@@H:41]4[CH2:44][CH2:43][NH:42]4)=[O:40])[CH:23]=3)[C:15]=2[N:16]=1)(=[O:10])[CH3:9].[CH:45](=O)[CH:46]([CH3:48])[CH3:47]>>[C:8]([NH:11][C:12]1[S:13][C:14]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[N:27]=[CH:26][N:25]=[C:24]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:35])([F:36])[F:37])=[CH:30][C:29]=4[NH:38][C:39]([C@@H:41]4[CH2:44][CH2:43][N:42]4[CH2:45][CH:46]([CH3:48])[CH3:47])=[O:40])[CH:23]=3)[C:15]=2[N:16]=1)(=[O:10])[CH3:9]

Participants

Reactant 2

HCID 6561Isobutyraldehyde

HCID 86607084HCID 86607084, compound

Product 1

HCID 58691420HCID 58691420, compound

Procedure

The title compound was prepared by reacting (2S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)azetidine-2-carboxamide trifluoroacetic acid salt [Example 37(c)] with isobutyraldehyde (Aldrich) under the conditions of Example 3(d). MS (ESI, pos. ion.) m/z: 585 (M+1). Mp: 174.4-174.9° C.

Sources & evidence

ORD record: ord-4f36c63e42264320a63266b20c2e170d
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07301022B2

Reaction notes

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