1-methyl-1H-imidazole-5-carbaldehyde → HCID 58691383, compound

HRID 1594483Notes

Reaction equation

HRID 1594483 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[C:12]1[N:17]=[CH:16][N:15]=[C:14]([O:18][C:19]2[C:24]3[N:25]=[C:26]([NH:28][C:29](=[O:31])[CH3:30])[S:27][C:23]=3[CH:22]=[CH:21][CH:20]=2)[CH:13]=1.[CH3:32][N:33]1[C:37]([CH:38]=O)=[CH:36][N:35]=[CH:34]1>>[CH3:32][N:33]1[C:37]([CH2:38][NH:1][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:5]=[CH:4][C:3]=2[C:12]2[N:17]=[CH:16][N:15]=[C:14]([O:18][C:19]3[C:24]4[N:25]=[C:26]([NH:28][C:29](=[O:31])[CH3:30])[S:27][C:23]=4[CH:22]=[CH:21][CH:20]=3)[CH:13]=2)=[CH:36][N:35]=[CH:34]1

Participants

3

Reactant 2

HCID 5735921-methyl-1H-imidazole-5-carbaldehydeHCID 21865046N-(4-(6-(2-Amino-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide

Product 1

HCID 58691383HCID 58691383, compound

Procedure

N-(4-(6-(2-Amino-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide (prepared as described in WO04014871) was reacted with 1-methyl-1H-imidazole-5-carbaldehyde (Acros) under the conditions of Example 54 to give the title compound. MS (ESI, pos. ion) m/z: 540 (M+1). Mp: 263.0-265.2° C.

Sources & evidence

ORD record
ord-bb2d392a043c46d385dac18005e3116c
Source dataset
uspto-grants-2007_11
Patent number
US07301022B2

Reaction notes

Loading…