Carbonic acid, ethyl 2-mercaptoethyl ester → HCID 15549934, compound

HRID 1594625Notes

Reaction equation

HRID 1594625 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C(=O)(O[CH2:20][CH2:21][SH:22])OCC>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][N:10]([CH2:20][CH2:21][SH:22])[CH2:11][CH2:12]2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 79728Carbonic acid, ethyl 2-mercaptoethyl esterHCID 36998414-(4-Fluoro-benzyl)-piperidine

Product 1

HCID 15549934HCID 15549934, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4-(4-fluorobenzyl)piperidine (5.9 g, 30.5 mmol) and ethyl 2-mercaptoethyl carbonate (4.8 g, 32 mmol) was heated to reflux in toluene (250 mL) for 18 hr under a nitrogen atmosphere. The toluene was removed in vacuo and the resulting oil was used without purification in the next step.

Workup

  1. temperaturewas heated
  2. customThe toluene was removed in vacuo
  3. customthe resulting oil was used without purification in the next step

Sources & evidence

ORD record
ord-ff6ecf6aea2f419191c39345aaa90516
Source dataset
uspto-grants-2001_09
Patent number
US06284774B1

Reaction notes

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