HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N'-Hydroxy-3-(pyridin-3-yl)propanimidamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 3-(Pyridin-3-yl)propanenitrile | HCID 10011930 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | N'-Hydroxy-3-(pyridin-3-yl)propanimidamide | HCID 53434814 | 61% |
Reaction Steps
20.1 g (0.15 mol) of 3-(3-pyridyl)propionitrile is dissolved in a mixture of 61 ml of ethanol, and 15 ml of water and 9.5 g (0.14 mol) of hydroxylamine hydrochloride and 21 g (0.15 mol) of K2CO3 are added. After 24 hours at reflux, the solvent is removed in a vacuum, and the residue is extracted twice with ethanol. The extracts are concentrated by evaporation and recrystallized in hot ethanol. 14.1 g (56%) of product is obtained. Melting point 119-121° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284779B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-b393dc8caa744229825b536b32bbf8e9 |
| Source note | uspto-grants-2001_09 |