反应详情

20.1 g (0.15 mol) of 3-(3-pyridyl)propionitrile is dissolved in a mixture of 61 ml of ethanol, and 15 ml of water and 9.5 g (0.14 mol) of hydroxylamine hydrochloride and 21 g (0.15 mol) of K2CO3 are added. After 24 hours at reflux, the solvent is removed in a vacuum, and the residue is extracted twice with ethanol. The extracts are concentrated by evaporation and recrystallized in hot ethanol. 14.1 g (56%) of product is obtained. Melting point 119-121° C.

1. additionare added
2. temperatureAfter 24 hours at reflux
3. customthe solvent is removed in a vacuum
4. extractionthe residue is extracted twice with ethanol
5. concentrationThe extracts are concentrated by evaporation
6. customrecrystallized in hot ethanol