1-Hexyl-4-methyl-3-nitro-5-phenyl-2-pyridone → 3-Amino-1-hexyl-4-methyl-5-phenyl-2-pyridone

HRID 1594671Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1594671
[CH2:1]([N:7]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10]([CH3:19])=[C:9]([N+:20]([O-])=O)[C:8]1=[O:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]>C(OCC)(=O)C.[Pd]>[NH2:20][C:9]1[C:8](=[O:23])[N:7]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10]=1[CH3:19]

Komponenten

4

Edukt 1

HCID 217065401-Hexyl-4-methyl-3-nitro-5-phenyl-2-pyridone

Produkt 1

HCID 217065113-Amino-1-hexyl-4-methyl-5-phenyl-2-pyridoneAusbeute 97,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 1-hexyl-4-methyl-3-nitro-5-phenyl-2-pyridone (0.093 g, 0.30 mmol) and 10% Pd/C in ethyl acetate (100 mL) was hydrogenated at 45 psi in a Parr apparatus for 4 hours. The catalyst was removed by filtration, and the solvent was evaporated to give 3-amino-1-hexyl-4-methyl-5-phenyl-2-pyridone (0.083 g, 97%).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-94d29d1a64024ede812b05663dcfa3f4
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06284768B1

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