4-Toluenesulfonyl chloride → (RS)-2-Phenyl-1-(toluene-4-sulfonyl)-pyrrolidine

HRID 1594693Notes

Reaction equation

HRID 1594693 reaction equation
[C:1]1([CH:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:12]1([CH3:22])[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[C:1]1([CH:7]2[CH2:11][CH2:10][CH2:9][N:8]2[S:18]([C:15]2[CH:16]=[CH:17][C:12]([CH3:22])=[CH:13][CH:14]=2)(=[O:20])=[O:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 2618922-Phenylpyrrolidine

Product 1

HCID 9796397(RS)-2-Phenyl-1-(toluene-4-sulfonyl)-pyrrolidine

Procedure

The title compound, white solid, m.p. 109° C. and MS: m/e=301 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-phenyl-pyrrolidine and toluene-4-sulfonyl chloride.

Sources & evidence

ORD record
ord-8845624acb1b43c59c159d1c9cd59220
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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