4-Acetylbenzenesulfonyl chloride → (RS)-1-{4-[2-(4-Fluoro-phenyl)-pyrrolidine-1-sulfonyl]-phenyl}-ethanone

HRID 1594714Notes

Reaction equation

HRID 1594714 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[C:13]([C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1)(=[O:15])[CH3:14]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2[S:22]([C:19]2[CH:18]=[CH:17][C:16]([C:13](=[O:15])[CH3:14])=[CH:21][CH:20]=2)(=[O:24])=[O:23])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2664184-Acetylbenzenesulfonyl chlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 21706702(RS)-1-{4-[2-(4-Fluoro-phenyl)-pyrrolidine-1-sulfonyl]-phenyl}-ethanone

Procedure

The title compound, pale brown solid, m.p. 148° C. and MS: m/e=348 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-acetyl-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-5b7b2ce2200f46388468d7a254bf607e
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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