4-Toluenesulfonyl chloride → 1-(4-Methylbenzenesulfonyl)-2-(3-methylphenyl)pyrrolidine

HRID 1594715Notes

Reaction equation

HRID 1594715 reaction equation
[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)[CH:2]=1.[C:13]1([CH3:23])[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>>[C:13]1([CH3:23])[CH:18]=[CH:17][C:16]([S:19]([N:8]2[CH2:9][CH2:10][CH2:11][CH:7]2[C:3]2[CH:2]=[C:1]([CH3:12])[CH:6]=[CH:5][CH:4]=2)(=[O:21])=[O:20])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 35440982-(3-Methylphenyl)pyrrolidine

Product 1

HCID 112900261-(4-Methylbenzenesulfonyl)-2-(3-methylphenyl)pyrrolidine

Procedure

The title compound, off-white solid, m.p. 79° C. and MS: m/e=315 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-m-tolyl-pyrrolidine and toluene-4-sulfonyl chloride.

Sources & evidence

ORD record
ord-df6ff040b81445c4bb0ef6795d616176
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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