4-Fluorobenzenesulfonyl chloride → (RS)-1-(4-Fluoro-benzenesulfonyl)-2-m-tolyl-pyrrolidine

HRID 1594716Notes

Reaction equation

HRID 1594716 reaction equation
[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)[CH:2]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:8]2[CH2:9][CH2:10][CH2:11][CH:7]2[C:3]2[CH:2]=[C:1]([CH3:12])[CH:6]=[CH:5][CH:4]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 35440982-(3-Methylphenyl)pyrrolidine

Product 1

HCID 21706703(RS)-1-(4-Fluoro-benzenesulfonyl)-2-m-tolyl-pyrrolidine

Procedure

The title compound, off-white solid, m.p. 80° C. and MS: m/e=319(M+) was prepared in accordance with the general method of example 1e from (RS)-2-m-tolyl-pyrrolidine and 4-fluoro-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-466ee71548d348d991dbdf758148328d
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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