4-Toluenesulfonyl chloride → HCID 21706694, compound

HRID 1594727Notes

Reaction equation

HRID 1594727 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[C:14]1([CH3:24])[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][N:10]2[S:20]([C:17]2[CH:18]=[CH:19][C:14]([CH3:24])=[CH:15][CH:16]=2)(=[O:22])=[O:21])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 21706772HCID 21706772, compound

Product 1

HCID 21706694HCID 21706694, compound

Procedure

The title compound, off-white solid, m.p. 96° C. and MS: m/e=354.2 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(3-chloro-4-fluoro-phenyl)-pyrrolidine and toluene-4-sulfonyl chloride.

Sources & evidence

ORD record
ord-fddf65238d464e1f8b00039ecdd25761
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

Loading…