4-(Trifluoromethyl)benzenesulfonyl chloride → (RS)-2-(4-Fluoro-phenyl)-1-(4-trifluoromethyl-benzenesulfonyl)-pyrrolidine

HRID 1594743Notes

Reaction equation

HRID 1594743 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[F:13][C:14]([F:26])([F:25])[C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2[S:21]([C:18]2[CH:17]=[CH:16][C:15]([C:14]([F:13])([F:25])[F:26])=[CH:20][CH:19]=2)(=[O:23])=[O:22])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 38655602-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 21706704(RS)-2-(4-Fluoro-phenyl)-1-(4-trifluoromethyl-benzenesulfonyl)-pyrrolidine

Procedure

The title compound, white solid, m.p. 85° C. and MS: m/e=373 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-trifluoromethyl-benzenesulfonyl chloride.

Sources & evidence

ORD record
ord-7240e6137dae44d690d4daa03687434c
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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