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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1594743Generated: October 25, 2026

4-(Trifluoromethyl)benzenesulfonyl chloride → (RS)-2-(4-Fluoro-phenyl)-1-(4-trifluoromethyl-benzenesulfonyl)-pyrrolidine

https://huagongshe.com/reaction/1594743

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzenesulfonyl chlorideHCID 2777399—
Reactant2-(4-Fluorophenyl)pyrrolidineHCID 3865560—
Product(RS)-2-(4-Fluoro-phenyl)-1-(4-trifluoromethyl-benzenesulfonyl)-pyrrolidineHCID 21706704—

Reaction Steps

The title compound, white solid, m.p. 85° C. and MS: m/e=373 (M+) was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-trifluoromethyl-benzenesulfonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06284785B1
Source datasetuspto-grants-2001_09
ORD IDord-7240e6137dae44d690d4daa03687434c
Source noteuspto-grants-2001_09