4-Toluenesulfonyl chloride → HCID 21706708, compound

HRID 1594767Notes

Reaction equation

HRID 1594767 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([CH3:13])[CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[C:14]1([CH3:24])[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH:12]([CH3:13])[CH2:11][CH2:10][N:9]2[S:20]([C:17]2[CH:18]=[CH:19][C:14]([CH3:24])=[CH:15][CH:16]=2)(=[O:22])=[O:21])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 4444550HCID 4444550, compound

Product 1

HCID 21706708HCID 21706708, compound

Procedure

The title compound, off-white solid, m.p. 112° C. and MS: m/e=354.2 (M+) was prepared in accordance with the general method of example 1e from (2RS,3RS)-2-(4-fluoro-phenyl)-3-methyl-pyrrolidine and toluene-4-sulfonyl chloride.

Sources & evidence

ORD record
ord-7a7509e82d3346df9eb35914624643bf
Source dataset
uspto-grants-2001_09
Patent number
US06284785B1

Reaction notes

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