HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 1-Trimethylsilanyl-azepan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Caprolactam | HCID 7768 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Trimethylsilanyl-azepan-2-one | HCID 11423999 | — |
Reaction Steps
Caprolactam, commercially available from Maybridge, (10.0 g, 88.0 mmol), Et3N (14.8 mL, 106 mmol) and chlorotrimethylsilane (13.5 mL, 106 mmol) were dissolved in toluene (60 mL) and refluxed under Ar for 3 h. The reaction was filtered and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284755B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-c52cf5aacac64d75bb086d4b6733f97c |
| Source note | uspto-grants-2001_09 |