HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Ammonium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 3-Ethylhexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one | HCID 2794573 | — |
| Reactant | {2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester | HCID 70159417 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | [2-(3-{4-cyano-3-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzyl}-2-methyl-3H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester | HCID 54508564 | — |
Reaction Steps
Following the procedure outlined in Example 2, but using {2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester (as described in Step A above) (0.60 g, 1.67 mmol) and 3-ethyl-3-(3-hydroxy-phenyl)-1-methyl-azepan-2-one (0.41 g, 1.67 mmol), the title compound was obtained after chromatography (CH2Cl2:CH3OH:NH4OH, 98:2:0.2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284755B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-d35ba693f19b448c9334bb724619cca8 |
| Source note | uspto-grants-2001_09 |