HRID1594861

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID2794573

3-Ethyl-3-(3-hydroxyphenyl)-1-methylazepan-2-one

C15H21NO2

结构：Cc1ncc(CCNC(=O)OC(C)(C)C)n1Cc1ccc(C#N)c(F)c1

HCID70159417

未命名化合物

PRODUCTS

生成物

HCID14923

Ammonium hydroxide

H5NO

结构：CCC1(c2cccc(Oc3cc(Cn4c(CCNC(=O)OC(C)(C)C)cnc4C)ccc3C#N)c2)CCCCN(C)C1=O

HCID54508564

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Following the procedure outlined in Example 2, but using {2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester (as described in Step A above) (0.60 g, 1.67 mmol) and 3-ethyl-3-(3-hydroxy-phenyl)-1-methyl-azepan-2-one (0.41 g, 1.67 mmol), the title compound was obtained after chromatography (CH2Cl2:CH3OH:NH4OH, 98:2:0.2).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d35ba693f19b448c9334bb724619cca8
来源数据集: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06284755B1
来源说明: uspto-grants-2001_09

反应 SMILES

[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH2:9][C:10]1[N:11]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[C:19](F)[CH:18]=2)[C:12]([CH3:15])=[N:13][CH:14]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:27]([C:29]1([C:38]2[CH:43]=[CH:42][CH:41]=[C:40]([OH:44])[CH:39]=2)[CH2:35][CH2:34][CH2:33][CH2:32][N:31]([CH3:36])[C:30]1=[O:37])[CH3:28].C(Cl)Cl>CO>[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH2:9][C:10]1[N:11]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[C:19]([O:44][C:40]3[CH:41]=[CH:42][CH:43]=[C:38]([C:29]4([CH2:27][CH3:28])[CH2:35][CH2:34][CH2:33][CH2:32][N:31]([CH3:36])[C:30]4=[O:37])[CH:39]=3)[CH:18]=2)[C:12]([CH3:15])=[N:13][CH:14]=1)([CH3:4])([CH3:3])[CH3:2].[NH4+:7].[OH-:5]