3-Ethylhexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one → 2-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[-(3-methyl-3-H-imidazol-4-yl)-cyclopropyl]-benzonitrile

HRID 1594891Notes

Reaction equation

HRID 1594891 reaction equation
F[C:2]1[CH:9]=[C:8]([C:10]2([C:13]3[N:14]([CH3:18])[CH:15]=[N:16][CH:17]=3)[CH2:12][CH2:11]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH2:19]([C:21]1([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([OH:36])[CH:31]=2)[CH2:27][CH2:26][CH2:25][CH2:24][N:23]([CH3:28])[C:22]1=[O:29])[CH3:20]>>[CH2:19]([C:21]1([C:30]2[CH:31]=[C:32]([CH:33]=[CH:34][CH:35]=2)[O:36][C:2]2[CH:9]=[C:8]([C:10]3([C:13]4[N:14]([CH3:18])[CH:15]=[N:16][CH:17]=4)[CH2:12][CH2:11]3)[CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH2:27][CH2:26][CH2:25][CH2:24][N:23]([CH3:28])[C:22]1=[O:29])[CH3:20]

Participants

3

Reactant 2

HCID 27945733-Ethylhexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-oneHCID 217062892-fluoro-4-[1-(3-methyl-3-H-imidazol-4-yl)-cyclopropyl]-benzonitrile

Product 1

HCID 99124822-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[-(3-methyl-3-H-imidazol-4-yl)-cyclopropyl]-benzonitrile

Procedure

Using the procedure described in Example 3, the title compound was prepared starting with 2-fluoro-4-[1-(3-methyl-3-H-imidazol-4-yl)-cyclopropyl]-benzonitrile (as described in Step A above) (0.050 g, 0.21 mmol) and 3-ethyl-3-(3-hydroxy-phenyl)-1-methyl-azepan-2-one (0.078 g, 0.21 mmol).

Sources & evidence

ORD record
ord-901295ff19034049a3af6c3974f54ebf
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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