HCID 21706154, compound → HCID 21706292, compound

HRID 1594898Notes

Reaction equation

HRID 1594898 reaction equation
[CH2:1]([C:4]1[C:9]([Br:10])=[CH:8][N:7]=[CH:6][C:5]=1[CH:11]([OH:21])[C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[C:14]([F:20])[CH:13]=1)[CH:2]=[CH2:3]>C(Cl)Cl.O=[Mn]=O>[CH2:1]([C:4]1[C:9]([Br:10])=[CH:8][N:7]=[CH:6][C:5]=1[C:11]([C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[C:14]([F:20])[CH:13]=1)=[O:21])[CH:2]=[CH2:3]

Participants

4

Reactant 1

HCID 21706154HCID 21706154, compound

Product 1

HCID 21706292HCID 21706292, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-[(4-allyl-5-bromo-pyridine-3-yl)-hydroxy-methyl]-2-fluoro-benzonitrile (as described above in Step B) (0.42 g, 1.21 mmol) in CH2Cl2 (50 mL) was added MnO2 (1.58 g, 18.1 mmol). After 6 hr the reaction was filtered and the CH2Cl2 was removed in vacuo to obtain the title compound.

Workup

  1. filtrationAfter 6 hr the reaction was filtered
  2. customthe CH2Cl2 was removed in vacuo

Sources & evidence

ORD record
ord-d8e9d249c0a04ca8950fe2168433448d
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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