Trifluoroacetic acid → HCID 21706296, compound

HRID 1594909Notes

Reaction equation

HRID 1594909 reaction equation
C([NH:5][C:6]([NH:8][CH2:9][CH2:10][N:11]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]([CH2:26][CH3:27])([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[C:12]1=[O:28])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:26]([C:13]1([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH2:14][CH2:15][CH2:16][CH2:17][N:11]([CH2:10][CH2:9][NH:8][C:6]([NH2:5])=[O:7])[C:12]1=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 217062861-Tert-butyl-3-{2-[3-ethyl-3-(3-methoxy-phenyl)-2-oxo-azepan-1-yl]-ethyl}-urea

Product 1

HCID 21706296HCID 21706296, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-tert-butyl-3-{2-[3-ethyl-3-(3-methoxy-phenyl)-2-oxo-azepan-1-yl]-ethyl}-urea (as described above in Step A) (0.35 g, 0.93 mmol) in CH2Cl2 (2.0 mL) was added TFA (6.0 mL) and the solution was stirred for 72 hr. The solvents were removed in vacuo to obtain the title compound.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-df29fbf52a094e4d90b85b5c52147034
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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