反应详情

温度

25 °C

To a solution of {2-[3-ethyl-3-(3-methoxy-phenyl)-2-oxo-azepan-1-yl]-ethyl}-urea (as described above in Step B) (0.14 g, 0.421 mmol) in CH2Cl2 (10 mL) at −78° C. was added BBr3 (1M, 0.842 mL, 0.842 rnmol). After stirring for 1 hr at 25° C. the reaction was quenched with H2O and partitioned with EtOAc and 10% HCl. The organic layer was washed with brine and dried (MgSO4), and the solvent removed in vacuo to obtain the title compound.

1. customwas quenched with H2O
2. custompartitioned with EtOAc and 10% HCl
3. washThe organic layer was washed with brine
4. dry with materialdried (MgSO4)
5. customthe solvent removed in vacuo