Boron tribromide → {2-[3-Ethyl-3-(3-hydroxy-phenyl)-2-oxo-azepan-1-yl]-ethyl}-urea

Participants

Reaction Conditions

Reaction Steps

To a solution of {2-[3-ethyl-3-(3-methoxy-phenyl)-2-oxo-azepan-1-yl]-ethyl}-urea (as described above in Step B) (0.14 g, 0.421 mmol) in CH2Cl2 (10 mL) at −78° C. was added BBr3 (1M, 0.842 mL, 0.842 rnmol). After stirring for 1 hr at 25° C. the reaction was quenched with H2O and partitioned with EtOAc and 10% HCl. The organic layer was washed with brine and dried (MgSO4), and the solvent removed in vacuo to obtain the title compound.

Provenance & Evidence