Boron tribromide → HCID 21706220, compound

HRID 1594911Notes

Reaction equation

HRID 1594911 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH3:30])[CH2:10][CH2:11][N:12]1[CH2:18][CH2:17][CH2:16][CH2:15][C:14]([CH2:27][CH3:28])([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25]C)[CH:20]=2)[C:13]1=[O:29].B(Br)(Br)Br>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:30][N:9]([CH3:8])[CH2:10][CH2:11][N:12]1[CH2:18][CH2:17][CH2:16][CH2:15][C:14]([CH2:27][CH3:28])([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([OH:25])[CH:20]=2)[C:13]1=[O:29]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 21706261HCID 21706261, compound

Product 1

HCID 21706220HCID 21706220, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 1-(2-dimethylamino-ethyl)-3-ethyl-3-(3-methoxy-phenyl)-azepan-2-one Trifluoroacetate (as described above in Step A) (0.1 g, 0.23 mmol) in CH2Cl2 (10 mL) at −78° C. was added BBr3 (1M, 0.46 mL, 0.46 mmol). After stirring for 2 hr at 25° C. the reaction mixture was quenched with H2O, the solvents removed in vacuo, and the residue purified by prep RP HPLC to obtain the title compound.

Workup

  1. customwas quenched with H2O
  2. customthe solvents removed in vacuo
  3. customthe residue purified by prep RP HPLC

Sources & evidence

ORD record
ord-dd5e39e2c75742ff8f1ccd78dd940b24
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

Loading…