反应详情

2-(3-Methoxyphenyl)-cyclohexanone, as described in Step A above, (0.61 g, 3 mmol), hydroxylamine hydrochloride (0.40 g, 6 mmol) and sodium acetate (0.80, 6.2 mmol) were combined in EtOH (4 mL): H2O (2 mL) and heated at reflux for 3 h. The reaction mixture was concentrated, then partitioned between EtOAc (100 mL) and H2O (100 mL), the organic layer separated, washed with H2O, brine, and dried (MgSO4). Filtration and concentration to dryness gave the title compound.

1. temperatureat reflux for 3 h
2. concentrationThe reaction mixture was concentrated
3. custompartitioned between EtOAc (100 mL) and H2O (100 mL)
4. customthe organic layer separated
5. washwashed with H2O, brine
6. dry with materialdried (MgSO4)
7. filtrationFiltration and concentration to dryness