(+)-4-[1-amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-fluoro-benzonitrile → 4-[1-amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(morpholine-4-sulfonyl)-phenoxy]-benzonitrile
Reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.F[C:18]1[CH:25]=[C:24]([C:26]([NH2:34])([C:28]2[N:29]([CH3:33])[CH:30]=[N:31][CH:32]=2)[CH3:27])[CH:23]=[CH:22][C:19]=1[C:20]#[N:21]>>[NH2:34][C:26]([C:24]1[CH:25]=[CH:18][C:19]([C:20]#[N:21])=[C:22]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)(=[O:10])=[O:9])[CH:3]=2)[CH:23]=1)([C:28]1[N:29]([CH3:33])[CH:30]=[N:31][CH:32]=1)[CH3:27]Participants
3
Procedure
Using the methods described in Example 24A, but substituting 3-hydroxybenzenesulfonylmorpholine (0.015 g, 0.061 mmol) and 2-fluoro-4-[1-amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-benzonitrile (as described in Example 24A, Step F), the title compound was prepared.
Sources & evidence
- ORD record
- ord-37ef510d6bd64289812cf94435ffb77a
- Source dataset
- uspto-grants-2001_09
- Patent number
- US06284755B1
Reaction notes
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