HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[5-(2-Amino-ethyl)-imidazol-1-ylmethyl]-2-fluoro-benzonitrile dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {2-[3-(4-cyano-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester | HCID 54495803 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-[5-(2-Amino-ethyl)-imidazol-1-ylmethyl]-2-fluoro-benzonitrile dihydrochloride | HCID 22627105 | — |
Reaction Steps
A solution of {2-[3-(4-cyano-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester (1.0 g, 0.0029 mmol) in EtOAc (30 mL) was cooled to −20° C. and saturated with HCl gas. The cooling bath was removed and the reaction was stirred for 2 hr. The solvent was removed in vacuo to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06284755B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-5f54e1617a154925ac388ab21c112c83 |
| Source note | uspto-grants-2001_09 |