Hydrochloric Acid → 4-[5-(2-Amino-ethyl)-imidazol-1-ylmethyl]-2-fluoro-benzonitrile dihydrochloride

HRID 1594929Notes

Reaction equation

HRID 1594929 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[N:11]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[C:18]([F:24])[CH:17]=2)[CH:12]=[N:13][CH:14]=1)(C)(C)C.[ClH:26]>CCOC(C)=O>[ClH:26].[ClH:26].[NH2:7][CH2:8][CH2:9][C:10]1[N:11]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[C:18]([F:24])[CH:17]=2)[CH:12]=[N:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54495803{2-[3-(4-cyano-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Product 1

HCID 226271054-[5-(2-Amino-ethyl)-imidazol-1-ylmethyl]-2-fluoro-benzonitrile dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of {2-[3-(4-cyano-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester (1.0 g, 0.0029 mmol) in EtOAc (30 mL) was cooled to −20° C. and saturated with HCl gas. The cooling bath was removed and the reaction was stirred for 2 hr. The solvent was removed in vacuo to obtain the title compound.

Workup

  1. customThe cooling bath was removed
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-5f54e1617a154925ac388ab21c112c83
Source dataset
uspto-grants-2001_09
Patent number
US06284755B1

Reaction notes

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