Hydrochloric Acid → HCID 22627648, compound

HRID 1594932Notes

Reaction equation

HRID 1594932 reaction equation
[CH3:1][O:2][C:3]1[C:12]([O:13]C)=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([C:15]#[N:16])=[CH:10]2)=[CH:5][CH:4]=1.[Al+3].[Cl-].[Cl-].[Cl-].O.Cl>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:12]([OH:13])=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([C:15]#[N:16])=[CH:10]2)=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6451240Aluminum(III) ChlorideHCID 21706940HCID 21706940, compound

Product 1

HCID 22627648HCID 22627648, compoundYield 86.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

A solution of Example 1A (1 g) in methylene chloride (100 mL) at 0° C. was treated with AlCl3, stirred for 4 h at 0 ° C. and at room temperature for 18 h, poured into water (200 mL) containing 6N HCl (20 mL), stirred for 1 h and diluted with methylene chloride (100 mL). The layers were separated, and the organic layer was washed with brine and dried (MgSO4) to provide 810 mg of the title compound as an off-white solid.

Workup

  1. stirringstirred for 1 h
  2. customThe layers were separated
  3. washthe organic layer was washed with brine
  4. dry with materialdried (MgSO4)

Sources & evidence

ORD record
ord-d51360900bce4215ba8442989bcc9087
Source dataset
uspto-grants-2001_09
Patent number
US06284796B1

Reaction notes

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