Dimethyl Carbonate → L-Lysine
Reaction equation
Cl.[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].[OH-].[Na+].C(=O)(OC)OC>O>[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 14 °C
Procedure
372 g (2.0 mole) lysine hydrochloride in 900 g water are introduced into a 2 l stirred flask. A pH of 11.6 is adjusted by the addition of 152 g (3.8 mole) sodium hydroxide. After cooling to 13-15° C., 541 g (6.0 mole) dimethyl carbonate are added, and the reaction is initiated by intensive stirring. The reaction is finished after 7 h at this temperature. The pH was held constant throughout the reaction period at 11.5-11.7 by continuous dispensing of 430 ml sodium hydroxide (10%-concentration).
Sources & evidence
- ORD record
- ord-29590222d8c6430e9f6486a185779be0
- Source dataset
- uspto-grants-2001_09
- Patent number
- US06284892B1
Reaction notes
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