Dimethyl Carbonate → L-Lysine

Participants

Reaction Conditions

Reaction Steps

372 g (2.0 mole) lysine hydrochloride in 900 g water are introduced into a 2 l stirred flask. A pH of 11.6 is adjusted by the addition of 152 g (3.8 mole) sodium hydroxide. After cooling to 13-15° C., 541 g (6.0 mole) dimethyl carbonate are added, and the reaction is initiated by intensive stirring. The reaction is finished after 7 h at this temperature. The pH was held constant throughout the reaction period at 11.5-11.7 by continuous dispensing of 430 ml sodium hydroxide (10%-concentration).

Provenance & Evidence