Triethylamine → (s)-3,4-Epoxybutyric acid triethylamine salt

HRID 1595032Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1595032
C([O:4][C@H:5]([CH2:10]Br)[CH2:6][C:7]([OH:9])=[O:8])(=O)C.[CH2:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH3:13]>O>[CH2:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH3:13].[O:4]1[CH2:10][C@@H:5]1[CH2:6][C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 8471TriethylamineHCID 2733880(3S)-3-acetyloxy-4-bromobutanoic acid

Produkt 1

HCID 86757347(s)-3,4-Epoxybutyric acid triethylamine salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of distilled water (10 ml), (S)-3-acetoxy-4-bromobutyric acid (0.9 g, 0.004 mol) and triethylamine (1.21 g, 0.012 mol) was charged to 100 ml flask equipped with a thermometer, pH meter and agitator, and stirred at 0˜5° C. for 2 hours to give (S)-3,4-epoxybutyric acid triethylamine salt. It was confirmed by a NMR analysis that more than 99% (S)-3,4-epoxybutyric acid triethylamine salt was converted.

Aufarbeitung

  1. customequipped with a thermometer

Quellen und Nachweise

ORD-Eintrag
ord-32238e470f174471b5bd42be3c486417
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06284902B1

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