反应详情

2-(4-Octanoyl phenyl)ethyl p-toluene sulfonate (1.23 g) prepared in the above-described procedure was dissolved in 2-butanone (18 ml) to obtain a solution. Sodium iodide (550 mg) was added to the solution, and the solution was heated to reflux for 40 minutes. The reaction solution was concentrated, and the solution was partitioned with water-dichloromethane. The dichloromethane layer was washed with water, dried over anhydrous sodium sulfate, and concentrated to obtain 4′-(2-iodoethyl)octanophenone (1.09 g) in the form of white crystal.

1. customto obtain a solution
2. temperaturethe solution was heated
3. temperatureto reflux for 40 minutes
4. concentrationThe reaction solution was concentrated
5. customthe solution was partitioned with water-dichloromethane
6. washThe dichloromethane layer was washed with water
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated