Pyridine → HCID 69028441, compound

Temperature

0 °C

To solution of 18 (46 mg, 0.25 mmol) in 1 mL of CH2Cl2 was added dry pyridine (20 mg, 50 μL, 0.3 mmol) at 0° C. (FIG. 2C). The solution was stirred at 0° C. for 10 minutes followed by the addition of acetyl chloride (˜30 μL, 0.4 mmol). The reaction mixture was stirred overnight at 0° C. and then the solvent was removed under vacuo. The residue was partioned between water and EtOAc. The organic solution was washed with 1 M HCl (10 mL), water (50 mL), and then dried (MgSO4). The solvent was evaporated to afford a oil which was chromatographed on silica gel and eluted with hexanes:EtOAc (initially 70:30, then 50:50) to afford the desired product as a white solid (11 mg, 20% yield). 1H NMR (CDCl3) δ7.86-7.89 (d, 1 H, ArH), 7.46-7.44 (d, 1 H, ArH), 7.32-7.36 (t, 1 H, ArH), 2.45 (s, 3 H, SCH3), 2.38 (s, 3 H, CH3); FAB-MS 227 (MH+, 15) 226 (MH+ −1, 10), 167 (50), 157 (30), 102 (100).

1. stirringThe reaction mixture was stirred overnight at 0° C.
2. customthe solvent was removed under vacuo
3. washThe organic solution was washed with 1 M HCl (10 mL), water (50 mL)
4. dry with materialdried (MgSO4)
5. customThe solvent was evaporated
6. customto afford a oil which
7. customwas chromatographed on silica gel
8. washeluted with hexanes

ORD record

ord-79aad1de32064887a28ce579ce3e45aa

Source dataset

uspto-grants-2001_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06284918B1