反应详情

5%-palladium/carbon (716 mg) was added to a solution of Compound 3 (7.16 g, 25 mmole) in tetrahydrofuran (hereinafter called “THF”) (300 ml), followed by stirring for 72 hours under a hydrogen gas stream. The reaction mixture was filtered, and the solid was washed with methanol. The filtrate and the washing were combined, followed by concentration under reduced pressure. The residue was recrystallized from acetonitrile, whereby the title compound (4.14 g) was obtained (yield: 84%).

1. filtrationThe reaction mixture was filtered
2. washthe solid was washed with methanol
3. concentrationfollowed by concentration under reduced pressure
4. customThe residue was recrystallized from acetonitrile, whereby the title compound (4.14 g)
5. customwas obtained (yield: 84%)