反应详情

温度

90 °C

5 g of 4-amino-5-cyanoimidazole was suspended in 10 mL of DMF and 10 mL of trimethyl orthoacetate was added, followed by stirring at 90° C. for 30 minutes. The reaction solution was concentrated under reduced pressure and the residue was dilute with ethyl acetate, and then 4.2 g of desired compound deposited as a crystal was collected by filtration. The solution was concentrated and the residue was purified by silica gel column chromatograpy (eluent: ethyl acetate) and then recrystallized from ethyl acetate-n-hexane to obtain 2.9 g of a desired compound as a crystal.

1. concentrationThe reaction solution was concentrated under reduced pressure
2. additionthe residue was dilute with ethyl acetate
3. filtrationwas collected by filtration
4. concentrationThe solution was concentrated
5. customthe residue was purified by silica gel column chromatograpy (eluent: ethyl acetate)
6. customrecrystallized from ethyl acetate-n-hexane