反应详情

Lithium aluminium hydride (21 mmol) is added in small portions to 10 mmol of 6-aminonicotinamide in tetrahydrofuran. The mixture is heated at reflux for 72 hours, then brought to ambient temperature and hydrolyzed with water and then with a 1N sodium hydroxide solution. After stirring for one hour, the mixture is filtered through Celite and washed with an 85/15 tetrahydrofuran/methanol mixture. The solvents are then evaporated off and the residue obtained is purified by chromatography on silica gel to yield the expected product in the form of a white solid.

1. temperatureThe mixture is heated
2. temperatureat reflux for 72 hours
3. filtrationthe mixture is filtered through Celite
4. washwashed with an 85/15 tetrahydrofuran/methanol mixture
5. customThe solvents are then evaporated off
6. customthe residue obtained
7. customis purified by chromatography on silica gel