(R)-N-Boc-2-amino-3,3-diphenylpropionic acid → HCID 10736807, compound

HRID 1595217Notes

Reaction equation

HRID 1595217 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:23]([OH:25])=[O:24])[CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Rh]>[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:23]([OH:25])=[O:24])[CH:10]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 7019136(R)-N-Boc-2-amino-3,3-diphenylpropionic acid

Product 1

HCID 10736807HCID 10736807, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 702EthanolSolvent

Procedure

A solution of N-tert-butoxycarbonyl-(2R)-3,3-diphenylalanine (10 mmol) in ethanol is placed under hydrogen for one night in the presence of Rh/C (0.5 g). After removal of the catalyst by filtration, the solvent is evaporated off to yield the expected product.

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. customthe solvent is evaporated off

Sources & evidence

ORD record
ord-1cb21a4fc70a4513bff28f6be138e4b5
Source dataset
uspto-grants-2001_09
Patent number
US06288077B1

Reaction notes

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