反应详情

温度

90 °C

A stirred mixture of 3′-bromo-4′-methoxy-[1,1′-biphenyl]-4-carboxylic acid, ethyl ester (28.8 g, 86 mmol) and aqueous sodium hydroxide (35 mL of 2 M) in ethanol (690 mL) is heated at 90° C. for 2 h. The cooled mixture is then acidified with hydrochloric acid (200 mL of 1.0 M) and the resulting precipitate is filtered off and dried to give 3′-bromo-4′-methoxy-[1,1′-biphenyl]-4-carboxylic acid as a colourless crystalline solid.

1. filtrationthe resulting precipitate is filtered off
2. customdried