反应详情

温度

90 °C

A stirred mixture of 4′-methoxy-3′-(3-nitrophenyl)-[1,1′-biphenyl]-4-carboxylic acid, ethyl ester (1.88 g. 5 mmol) and aqueous sodium hydroxide (20 mL of 2 M) in ethanol (30 mL) is heated at 90° C. for 3 h. The cooled mixture was then acidified with hydrochloric acid (100 mL of 1.0 M) and the resulting precipitate is filtered off and dried to give 4′-methoxy-3′-(3-nitrophenyl) -[1,1′-biphenyl]-4-carboxylic acid as a colourless crystalline solid, m.p. 270-274° C.

1. filtrationthe resulting precipitate is filtered off
2. customdried