反应详情

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate (13.7 g) and 1-naphthalenemethylamine (11.0 g) were dissolved in xylene (137 ml), andrefluxed underheating for 9 hr whiledehydrating with Dean-stark trap. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and dried. The solvent was concentrated under reduced pressure and isopropyl alcohol was added to the obtained residue to allow crystallization. The crystals were collected by filtration to give ethyl 5-(4-methylphenyl)-2-(1-naphthyl)-imidazole-4-carboxylate (2.5 g), melting point 190-192° C.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with water
3. customdried
4. concentrationThe solvent was concentrated under reduced pressure and isopropyl alcohol
5. additionwas added to the obtained residue
6. customcrystallization
7. filtrationThe crystals were collected by filtration